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Department of Bio-Chemistry | Final Year Research Project Topics | Download Free Projects

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  • INCIDENCE OF OBESITY AND ITS PREDISPOSITION TO METABOLIC SYNDROME AMONG FEMALE STUDENTS

    » ABSTRACT The incidence of obesity was studied in three-hundred and five (305) female subjects in the University of Nigeria, Nsukka in the age groups 16-18 years, 19-21 years, 22-24 years and 25-27 years using two anthropometric indices of obesity: body mass index (BMI) and waist circumference (WC). A short structured questionnaire was administered to the subjects to elicit information on personal data, physical activity, lifestyle and family history. Metabolic syndrome was assessed in one hundred and thirty nine subjects of the total population using the NCEP: ATPIII/IDF 2001 criteria for individuals sixteen years (16 years) and older. Of the subjects in the total population, 5.2% were obese measured by BMI and 10.3% obese as measured by WC. Mean values were found to be higher in age groups 22-24 years and 25-27 years (BMI: 34.04 ± 3.30, 40.14 ± 0) (WC: 96.77 ± 7.32, 96.00 ± 11.31). The prevalence of metabolic syndrome was found to be 5.7% and all subjects with the syndrome were centrally obese. Low high density lipoprotein cholesterol (HDL-C) level had the highest prevalence (90.6%) of the individual components of the metabolic syndrome. Correlation analysis revealed a positive association between WC and BMI, WC and blood pressure (BP) and a negative but insignificant correlation between WC and HDL-C. Family history had a significant effect (P=0.00) on the BMI and WC of the subjects but there was a non-significant effect of subject’s lifestyle on BMI and WC. The results of this study showed that obesity is not just prevalent among the study population but also a predisposing factor to metabolic syndrome. ...Continue Reading »

    Item Type: Project Material |  85 Pages  |  2,087 engagements |  Share

  • IMPACT OF CELL ARRIVAL PROCESS ON A DYNAMIC CALL ADMISSION CONTROLBASED ATM NETWORK

    » ABSTRACT vi Network congestion control is comprised of connection admission control (CAC) and network policing control (NPC). Dynamic Call Admission Control (DCAC) is a class in CAC primarily intended to achieve network protection from congestion thereby enhancing network performance and utilization. ATM network is sensitive to varying traffic intensity and the accompanying QoS requirements. sys Therefore, ATM based CAC tem is chosen because of the distinct position it occupies in the present network technology. This Thesis investigates the impact of variations in cell arrival process on the DCAC using cell burstiness as parameter. Equally, DCAC is investigated based on QoS parameters such as cell loss probability, cell delay and cell occupancy. Computer modeling and simulation techniques are employed. The simulation results obtained show that varying the cell arrival process brings about variation in the QoS metrics and so, the different cell arrival distribution models have different impacts on the Dynamic Call Admission Control (DCAC),...Continue Reading »

    Item Type: Project Material |  88 pages |  2,087 engagements |  Share

  • COMPARATIVE EFFECTS OF ESCULETIN AND SCOPOLETIN ON PARACETAMOLINDUCED LIVER DAMAGE IN RATS

    » ABSTRACT A wide spectrum of pharmacological activities is displayed by coumarins and their derivatives. Coumarins are bonzo-α-pyrones. They are active components of herbs used for the treatment of various diseases such as cancers, hypertension, etc. Esculetin (6,7- dihydroxy coumarin) is a phenolic antioxidant and scopoletin (7-hydroxy-6- methoxycoumarin) is one of the most widespread coumarins in nature. The comparative effects of esculetin and scopoletin on paracetamol induced liver damage in rats were investigated. Aspartate aminotransferase, alanine aminotransferase, alkaline aminotransferase and superoxide dismutase activities were assayed and total and conjugated bilirubin level, malondialdehyde, albumin and globulin levels were analyzed. The results showed that the enzyme levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) in the serum of the rats treated with paracetamol (positive control) increased significantly (P<0.05) as compared with the group administered distilled water (negative control). The result also showed that total bilirubin and conjugated bilirubin level increased significantly (P<0.05) as compared with the negative control. No significant difference (P>0.05) was observed in the activities of the enzyme markers assayed between the test groups administered esculetin plus paracetamol and scopoletin plus paracetamol. Significant difference (P<0.05) was observed between the test groups and the positive control. No significant difference (P>0.05) was observed between the rats of the test groups and the negative control. . No significant difference (P>0.05) was observed between the level of serum proteins of the test groups and the positive and negative controls. Significant difference (P>0.05) was observed between the test groups and the positive control for the activity of superoxide dismutase and malondialdehyde levels. No significant difference (P<0.05) was observed between the test groups and the negative control for both the activity of superoxide dismutase and malondialdehyde level. There was a significant difference (P<0.05) between the ALP activities of the positive control and negative control. No significant differences (P<0.05) were observed between the ALT of the esculetin plus paracetamol and scopoletin plus paracetamol and the positive control. A significant difference (P<0.05) in the level of AST was observed between the positive control and the test groups administered esculetin plus paracetamol and scopoletin plus paracetamol. The results from this study suggest that esculetin and scopoletin have similar antioxidant effect on paracetamol induced liver damage in rats. H H H3CO HO O Scopoletin H O O Coumarin O HO HO O O Esculetin Fig. 1: Structures of Parent Coumarin, Scopoletin and Esculetin The distribution of biologically active coumarins in a wide range of plants seems to correlate with their ability to act as phytoalexins, i.e they are formed as a response to traumatic injury (Wikipedia, 2008). Coumarins have a variety of bioactivities including anticoagulant, estrogenic, dermal, photosensitizing, antimicrobial, vasodilatory, molluscidal, antihelmintic, sedative and hypnotic, analgesic and hypothermic activity (Ojala, 2001). Coumarin has a wide variety of uses in industry, mainly due to its strong fragrant odour (Tkach and Lukyanets, 1992). Its uses include that of a sweetener and fixative of perfumes (e.g. 3,4-dihydrocoumarin), an enhancer of natural oils, such as lavender, a food additive in combination with vanillin, a flavour/odour stabilizer in tobaccos, an odour masker in paints and rubbers and In addition, it is also used in electroplating to reduce the porosity and increase the brightness of various deposits such as nickels. Coumarin compounds are suggested to be beneficial for the plants themselves as natural biocontrolling antipathogenic compounds, and for human beings as dietary supplements on the basis of their mild antimicrobial and anti-inflammatory effects (SCCP, 2006). Coumarins are active components of herbs used for the treatment of various diseases (Moini et al., 2002...Continue Reading »

    Item Type: Project Material |  115 pages |  2,087 engagements |  Share


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